tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Base Information

Chemical Name:tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate
CAS No.:479064-36-3
Molecular Formula:C₃₀H₄₁NO₅Si
Molecular Weight:523.745
Hs Code.:

Synonyms:tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Suppliers and Price of tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

There total 4 articles about tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 479064-35-2
tert-butyl (2S,4R)-2-(but-3-enyl)-4-tert-butyldiphenylsilyloxy-2-formyl-1-pyrrolidinecarboxylate

: 479064-36-3
tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Guidance literature:: With oxygen; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(02)01292-9

Reference yield:

: 226225-42-9
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester

: 479064-36-3
tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / LDA; HMPA / tetrahydrofuran / -78 °C

2: 86 percent / DIBAH / toluene / 2 h / -78 °C

3: 93 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

4: 92 percent / CuCl; PdCl₂; oxygen / dimethylformamide; H₂O / 5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrapropylammonium perruthennate; 4 A molecular sieve; oxygen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; copper(l) chloride; palladium dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4: Wacker oxidation;
DOI:10.1016/S0040-4020(02)01292-9

Reference yield:

: 226225-51-0
2-but-3-enyl-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 479064-36-3
tert-butyl (2S,4R)-4-tert-butyldiphenylsilyloxy-2-formyl-2-(3-oxobutyl)-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / DIBAH / toluene / 2 h / -78 °C

2: 93 percent / tetrapropylammonium perruthenate; N-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

3: 92 percent / CuCl; PdCl₂; oxygen / dimethylformamide; H₂O / 5 h / 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; oxygen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; copper(l) chloride; palladium dichloride; In dichloromethane; water; N,N-dimethyl-formamide; toluene; 3: Wacker oxidation;
DOI:10.1016/S0040-4020(02)01292-9