Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester

Base Information

• Chemical Name: Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester
• CAS No.: 151259-53-9
• Molecular Formula: C₁₄H₁₅NO₄S₂
• Molecular Weight: 325.409
• Mol file: 151259-53-9.mol

Synonyms:Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester

Chemical Property of Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester

There total 3 articles about Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl N-p-tolylsulfonyl-2-imino-2-(2-thienyl)acetate (151259-50-6) → Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester (151259-53-9)

Guidance literature:

With aluminium trichloride; diphenylsilane; In dichloromethane; at 20 ℃; for 15h; also with triethylsilane;

DOI:10.1246/bcsj.63.2588

Reference yield:

methyl 2-thienylglyoxylate (26878-13-7) → Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester (151259-53-9)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. H₂SO₄ / methanol

2: Heating

3: 86 percent / 1eq. aluminium(III) chloride, diphenylsilane / CH₂Cl₂ / 15 h / 20 °C / also with triethylsilane

With aluminium trichloride; sulfuric acid; diphenylsilane; In methanol; dichloromethane;

DOI:10.1246/bcsj.63.2588

Reference yield:

Dimethoxy-thiophen-2-yl-acetic acid methyl ester (151259-51-7) → Thiophen-2-yl-(toluene-4-sulfonylamino)-acetic acid methyl ester (151259-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: 86 percent / 1eq. aluminium(III) chloride, diphenylsilane / CH₂Cl₂ / 15 h / 20 °C / also with triethylsilane

With aluminium trichloride; diphenylsilane; In dichloromethane;

DOI:10.1246/bcsj.63.2588

upstream raw materials:

methyl N-p-tolylsulfonyl-2-imino-2-(2-thienyl)acetate

methyl 2-thienylglyoxylate

Dimethoxy-thiophen-2-yl-acetic acid methyl ester