N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

Base Information

Chemical Name:N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride
CAS No.:66962-79-6
Molecular Formula:C₁₉H₃₉N₅O₆*3ClH
Molecular Weight:542.931
Hs Code.:

N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

Synonyms:N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

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Chemical Property of N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

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Technology Process of N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

There total 5 articles about N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67051-93-8
[(2R,3R,6S)-2-{(1R,2S,3S,4R,5S,6R)-2-Benzyloxycarbonylamino-5-[(2-dimethylamino-acetyl)-methyl-amino]-3,6-dihydroxy-4-methoxy-cyclohexyloxy}-6-(1-benzyloxycarbonylamino-ethyl)-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

: 66962-79-6
N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 4h; under 2280 Torr;
DOI:10.1016/S0008-6215(00)85134-4

Reference yield:

: 66962-55-8,71658-13-4,76822-42-9,78609-41-3,78781-05-2
1,2',6'-tri-N-(benzyloxycarbonyl)fortimicin B

: 66962-79-6
N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / 1-hydroxybenzotriazole monohydrate, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 24 h / Ambient temperature

2: H₂, 0.2 M HCl / 5 percent Pd/C / methanol / 4 h / 2280 Torr

With hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0008-6215(00)85134-4

Reference yield:

: 66962-56-9,71564-63-1,71873-76-2,73285-02-6,74742-44-2,76822-43-0,79703-12-1
1,2',6',2''-tetra-N-benzyloxycarbonyl-4-N-methyl-fortimicin A

: 66962-79-6
N-{(1S,2R,3R,4S,5S,6R)-4-Amino-3-[(2R,3R,6S)-3-amino-6-(1-amino-ethyl)-tetrahydro-pyran-2-yloxy]-2,5-dihydroxy-6-methoxy-cyclohexyl}-2-dimethylamino-N-methyl-acetamide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 0.165 g / 5 percent aq. NaHCO₃ / methanol / 4 h / Heating

2: 54 percent / 1-hydroxybenzotriazole monohydrate, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 24 h / Ambient temperature

3: H₂, 0.2 M HCl / 5 percent Pd/C / methanol / 4 h / 2280 Torr

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0008-6215(00)85134-4