4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile

Base Information

• Chemical Name: 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile
• CAS No.: 1395225-91-8
• Molecular Formula: C₂₁H₁₁Cl₂N₅S₂
• Molecular Weight: 468.39
• Mol file: 1395225-91-8.mol

Synonyms:4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile

Chemical Property of 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile

There total 3 articles about 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(5-(2-chloroacetyl)imidazo[2,1-b]thiazol-6-yl)benzonitrile (1395225-96-3) + N-[3,5-dichlorophenyl]thiourea (107707-33-5) → 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile (1395225-91-8)

Guidance literature:

In methanol; at 90 ℃; for 0.5h; under 12929 Torr; Microwave irradiation;

DOI:10.1016/j.tetlet.2012.06.116

Reference yield:

4-Cyanophenacyl bromide (20099-89-2) → 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile (1395225-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetone / Reflux

1.2: Reflux

2.1: 1,4-dioxane / 5.5 h / 70 - 104 °C

3.1: methanol / 0.5 h / 90 °C / 12929 Torr / Microwave irradiation

In 1,4-dioxane; methanol; acetone; 3.1: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.tetlet.2012.06.116

Reference yield:

4-(imidazo[2,1-b]thiazol-6-yl)benzonitrile (118001-67-5) → 4-(5-(2-(3,5-dichlorophenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6-yl)benzonitrile (1395225-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 5.5 h / 70 - 104 °C

2: methanol / 0.5 h / 90 °C / 12929 Torr / Microwave irradiation

In 1,4-dioxane; methanol; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.tetlet.2012.06.116

upstream raw materials:

4-Cyanophenacyl bromide

4-(imidazo[2,1-b]thiazol-6-yl)benzonitrile

4-(5-(2-chloroacetyl)imidazo[2,1-b]thiazol-6-yl)benzonitrile

N-[3,5-dichlorophenyl]thiourea