7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide

Base Information

• Chemical Name: 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide
• CAS No.: 1477486-37-5
• Molecular Formula: C₂₂H₂₇N₃O₂
• Molecular Weight: 365.475

Synonyms:7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide

Chemical Property of 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide

Chemical Property:

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Technology Process of 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide

There total 4 articles about 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-benzyl-N-[2-(tert-butylamino)-1-(1-methyl-1H-pyrrol-2-yl)-2-oxoethyl]but-2-ynamide (1477486-29-5) → 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide (1477486-37-5)

Guidance literature:

With platinum(II) chloride; In chloroform; at 50 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1339474

Reference yield:

tert-butylisonitrile (119072-55-8,7188-38-7) → 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide (1477486-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 48 h / 50 °C / Inert atmosphere

2: platinum(II) chloride / chloroform / 14 h / 50 °C / Inert atmosphere

With sodium sulfate; platinum(II) chloride; In methanol; chloroform; 1: |Ugi Condensation;

DOI:10.1055/s-0033-1339474

Reference yield:

N-methylpyrrole aldehyde (1192-58-1) → 7-benzyl-N-tert-butyl-1,4-dimethyl-6-oxo-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide (1477486-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 48 h / 50 °C / Inert atmosphere

2: platinum(II) chloride / chloroform / 14 h / 50 °C / Inert atmosphere

With sodium sulfate; platinum(II) chloride; In methanol; chloroform; 1: |Ugi Condensation;

DOI:10.1055/s-0033-1339474

upstream raw materials:

tert-butylisonitrile

N-benzyl-N-[2-(tert-butylamino)-1-(1-methyl-1H-pyrrol-2-yl)-2-oxoethyl]but-2-ynamide

N-methylpyrrole aldehyde

benzylamine

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