(S)-N-tosyl-2-piperidinylethanol

Base Information

Chemical Name:(S)-N-tosyl-2-piperidinylethanol
CAS No.:934472-38-5
Molecular Formula:C₁₄H₂₁NO₃S
Molecular Weight:283.392
Hs Code.:

Synonyms:(S)-N-tosyl-2-piperidinylethanol

Suppliers and Price of (S)-N-tosyl-2-piperidinylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-tosyl-2-piperidinylethanol

Chemical Property:

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Technology Process of (S)-N-tosyl-2-piperidinylethanol

There total 7 articles about (S)-N-tosyl-2-piperidinylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934472-37-4
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-piperidine

: 934472-38-5
(S)-N-tosyl-2-piperidinylethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1016/j.tetlet.2007.01.082

Reference yield:

: (R)-2-(1-tosylaziridin-2-yl)ethanol

: 934472-38-5
(S)-N-tosyl-2-piperidinylethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C

2.1: tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C

3.1: BH₃*DMS / tetrahydrofuran / 8 h / -10 - 20 °C

3.2: H₂O₂; NaOH / 2 h / 0 - 20 °C

4.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 0 - 20 °C

5.1: TBAF / tetrahydrofuran / 6 h / 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; diethyl ether; 4.1: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082

Reference yield:

: N-(3-hydroxy-1-hydroxymethylpropyl)-4-methylbenzenesulfonamide

: 934472-38-5
(S)-N-tosyl-2-piperidinylethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-(azodicarbonyl)dipiperidine; n-Bu₃P / toluene / 16 h / 0 - 20 °C

2.1: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C

3.1: tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C

4.1: BH₃*DMS / tetrahydrofuran / 8 h / -10 - 20 °C

4.2: H₂O₂; NaOH / 2 h / 0 - 20 °C

5.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 0 - 20 °C

6.1: TBAF / tetrahydrofuran / 6 h / 20 °C

With 1H-imidazole; tributylphosphine; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; diethyl ether; toluene; 1.1: Mitsunobu condensation / 5.1: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082