(2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene

Base Information

• Chemical Name: (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene
• CAS No.: 1112335-67-7
• Molecular Formula: C₁₈H₂₈ClNO₂
• Molecular Weight: 325.879

Synonyms:(2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene

Chemical Property of (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene

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Technology Process of (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene

There total 2 articles about (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-chloro 4-iodobutane (10297-05-9) + (S)-2-methyl-1-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>benzene (102069-92-1) → (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene (1112335-67-7)

Guidance literature:

(S)-2-methyl-1-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>benzene; With ammonia; potassium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; Inert atmosphere;

1-chloro 4-iodobutane; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol8029017

Reference yield:

1-chloro 4-iodobutane (10297-05-9) + (S)-2-methyl-1-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>benzene (102069-92-1) → (2'S,1R)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene + (2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene (1112335-67-7)

Guidance literature:

(S)-2-methyl-1-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>benzene; With ammonia; sodium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; Inert atmosphere;

1-chloro 4-iodobutane; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol8029017

Reference yield:

(2'S,1S)-2-methyl-1-(4'-chlorobutyl)-1-[{(2'-methoxymethyl)pyrrolidinyl}carbonyl]-2,5-cyclohexadiene (1112335-67-7) → C18H28INO2

Guidance literature:

With sodium iodide; In acetone; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/ol8029017

upstream raw materials:

1-chloro 4-iodobutane

(S)-2-methyl-1-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>benzene

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