(4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

Base Information

• Chemical Name: (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one
• CAS No.: 96914-43-1
• Molecular Formula: C₂₈H₃₇N₃O
• Molecular Weight: 431.621

Synonyms:(4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

Chemical Property of (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

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Technology Process of (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one

There total 2 articles about (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + (+/-)-α-(R*)-<2-ethyl>-α-(4-phenylphenyl)-2(R*)-piperidineacetamide (96914-34-0) → (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one (96914-43-1)

Guidance literature:

at 80 ℃; for 12.5h;

DOI:10.1021/jm00147a029

Reference yield:

(+/-)-α-<2-ethyl>-α-(4-phenylphenyl)-2-pyridineacetamide (91257-06-6) → (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one (96914-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / H₂SO₄, H₂ / PtO₂ / acetic acid / 4 h / 75 °C / 60 Torr

2: 49 percent / 12.5 h / 80 °C

With sulfuric acid; hydrogen; platinum(IV) oxide; In acetic acid;

DOI:10.1021/jm00147a029

Reference yield: 50.0%

(4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-4,4a,5,6,7,8-hexahydro-pyrido[1,2-c]pyrimidin-3-one (96914-43-1) → (4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-octahydro-pyrido[1,2-c]pyrimidin-3-one (96914-47-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00147a029

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

(+/-)-α-(R^*)-<2-ethyl>-α-(4-phenylphenyl)-2(R^*)-piperidineacetamide

(+/-)-α-<2-ethyl>-α-(4-phenylphenyl)-2-pyridineacetamide

Downstream raw materials:

(4R,4aR)-4-Biphenyl-4-yl-4-(2-diisopropylamino-ethyl)-octahydro-pyrido[1,2-c]pyrimidin-3-one

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