(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

Base Information

• Chemical Name: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride
• CAS No.: 1207533-91-2
• Molecular Formula: C₂₂H₂₀F₃N*ClH
• Molecular Weight: 391.864
• Mol file: 1207533-91-2.mol

Synonyms:(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

Chemical Property of (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride

There total 14 articles about (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(1-chloroprop-2-en-1-yl)-3-(trifluoromethyl)benzene (1273319-40-6) + (R)-1-(1-Naphthyl)ethylamine (3886-70-2) → (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride (1207533-91-2)

Guidance literature:

1-(1-chloroprop-2-en-1-yl)-3-(trifluoromethyl)benzene; (R)-1-(1-Naphthyl)ethylamine; With potassium carbonate; In acetonitrile; at 80 - 85 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In water; toluene; at 50 - 60 ℃; pH=0.1 - 0.5; Inert atmosphere;

Reference yield: 86.03%

1-[3-chloroprop-1-en-1-yl]-3-(trifluoromethyl)benzene (41412-73-1) + (R)-1-(1-Naphthyl)ethylamine (3886-70-2) → (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride (1207533-91-2)

Guidance literature:

1-[3-chloroprop-1-en-1-yl]-3-(trifluoromethyl)benzene; (R)-1-(1-Naphthyl)ethylamine; With potassium carbonate; In acetonitrile; at 80 - 85 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In water; toluene; at 50 - 60 ℃; pH=0.1 - 0.5; Inert atmosphere;

Reference yield: 77.0%

(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine → (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl-2-ene]-1-naphthalenemethaneamine hydrochloride (1207533-91-2)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 0 - 30 ℃; for 4.5h; Product distribution / selectivity;

upstream raw materials:

3-Trifluoromethylbenzaldehyde

(R)-1-(1-Naphthyl)ethylamine

1-[3-chloroprop-1-en-1-yl]-3-(trifluoromethyl)benzene

1-(1-chloroprop-2-en-1-yl)-3-(trifluoromethyl)benzene

Downstream raw materials:

(R)-tert-butyl (1-(naphthalen-1-yl)ethyl)(3-(3-(trifluoromethyl)phenyl)propyl)carbamate

C₂₇H₂₈F₃NO₂

cinacalcet hydrochloride

N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine citrate