2,3,4-Trimethoxybenzylamine

Base Information

• Chemical Name: 2,3,4-Trimethoxybenzylamine
• CAS No.: 41219-16-3
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.234
• Hs Code.: 2922199090
• European Community (EC) Number: 255-268-3
• NSC Number: 684914
• UNII: EI62WDO5GM
• DSSTox Substance ID: DTXSID10194146
• Nikkaji Number: J320.028K
• Wikidata: Q72513728
• Mol file: 41219-16-3.mol

Synonyms:2,3,4-Trimethoxybenzylamine;41219-16-3;(2,3,4-trimethoxyphenyl)methanamine;2,3,4-Trimethoxy-benzylamine;EI62WDO5GM;EINECS 255-268-3;NSC-684914;NSC684914;UNII-EI62WDO5GM;2,4-Trimethyloxybenzylamine;SCHEMBL165313;(2,3,4-trimethoxybenzyl)amine;2, 3, 4-trimethoxybenzylamine;DTXSID10194146;MFCD01310841;AKOS000127712;Benzenemethanamine, 2,3,4-trimethoxy-;NSC 684914;1-(2,3,4-trimethoxyphenyl)methanamine;AS-44277;CS-0216064;FT-0747217;EN300-33148;Z239626488

Chemical Property of 2,3,4-Trimethoxybenzylamine

Chemical Property:

• Appearance/Colour: Colorless to yellow clear liquid
• Vapor Pressure: 0.00269mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 286.1 °C at 760 mmHg
• PKA: 9.36±0.10(Predicted)
• Flash Point: 129.8 °C
• PSA: 53.71000
• Density: 1.087 g/cm³
• LogP: 1.87140
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 197.10519334
• Heavy Atom Count: 14
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

2,3,4-Trimethoxybenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)CN)OC)OC

Technology Process of 2,3,4-Trimethoxybenzylamine

There total 9 articles about 2,3,4-Trimethoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ 2,3,4-trimethoxybenzylamine (41219-16-3)

Guidance literature:

With ammonia; hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave;

Reference yield: 84.0%

N-(2,3,4-trimethoxybenzyl)phthalimide → 2,3,4-trimethoxybenzylamine (41219-16-3)

Guidance literature:

With hydrazine hydrate; In methanol; for 1h; Heating;

DOI:10.1016/j.tet.2004.04.011

Reference yield:

2,3,4-trimethoxybenzaldehyde (2103-57-3) → 2,3,4-trimethoxybenzylamine (41219-16-3)

Guidance literature:

With ammonia; hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave;

DOI:10.1039/d0gc02421j

upstream raw materials:

2,3,4-trimethoxybenzonitrile

chloro-acetic acid-(2,3,4-trimethoxy-benzylamide)

2,3,4-trimethoxy-benzoic acid amide

1,2,3-trimethoxybenzene

Refernces

• 1、 Cui, Zhibing,Liu, Jianguo,Liu, Qiying,Ma, Longlong,Singh, Thishana,Wang, Chenguang,Wang, Nan,Zhu, Yuting. "Facile synthesis of controllable graphene-co-shelled reusable Ni/NiO nanoparticles and their application in the synthesis of amines under mild conditions". supporting information. p. 7387 - 7397. Retrieved 2020/11/19.
• 2、 Lin,Driscoll. "Catecholamine analogs as potential antitumor agents. II". . p. 806 - 808. Retrieved 2007/10/02.