2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide

Base Information

• Chemical Name: 2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide
• CAS No.: 125728-57-6
• Molecular Formula: C₁₇H₁₈ClNOS
• Molecular Weight: 319.855
• Mol file: 125728-57-6.mol

Synonyms:2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide

Chemical Property of 2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide

There total 1 articles about 2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

2-chloro-N-phenethylacetamide (13156-95-1) + (4-chlorophenyl)methanethiol (6258-66-8) → 2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide (125728-57-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h;

DOI:10.1002/jps.2600781112

Reference yield:

2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide (125728-57-6) → N-<2-<<(4-chlorophenyl)methyl>thio>ethyl>benzeneethanamine (125698-14-8)

Guidance literature:

With hydrogenchloride; dimethylsulfide; borane; Yield given. Multistep reaction; 1) THF, methanol, overnight; 2) methanol, reflux, 45 min;

DOI:10.1002/jps.2600781112

Reference yield:

2-<<(4-chlorophenyl)methyl>thio>-N-(2-phenylethyl)acetamide (125728-57-6) → 3,4-dihydro-6-(4-chlorophenyl)-4-(2-phenylethyl)-2H-1,4-thiazine

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) borane, dimethylsulfide, 2.) aq. HCl / 1) THF, methanol, overnight; 2) methanol, reflux, 45 min

2: 1.) lithium diisopropylamide / 1) THF, 1 h, 0 deg C; 2) THF, 3.75 h

With hydrogenchloride; dimethylsulfide; borane; lithium diisopropyl amide;

DOI:10.1002/jps.2600781112

upstream raw materials:

2-chloro-N-phenethylacetamide

(4-chlorophenyl)methanethiol

Downstream raw materials:

N-<2-<<(4-chlorophenyl)methyl>thio>ethyl>benzeneethanamine