methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate

Base Information

• Chemical Name: methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate
• CAS No.: 1552301-91-3
• Molecular Formula: C₂₂H₂₄O₈
• Molecular Weight: 416.428
• Mol file: 1552301-91-3.mol

Synonyms:methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate

Chemical Property of methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate

There total 3 articles about methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(4'-hydroxyphenyl)ethyl methyl carbonate (953422-33-8) + methyl 3,4,5-trimethoxycinnamate (20329-96-8) → methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate (1552301-91-3)

Guidance literature:

With trifluoroacetic acid; at 25 ℃; for 24h; Temperature;

DOI:10.1039/c3nj01180a

Reference yield:

sinapinic acid (530-59-6,7362-37-0) → methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate (1552301-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / 25 °C

2: trifluoroacetic acid / 24 h / 25 °C

With potassium carbonate; trifluoroacetic acid; In acetone;

DOI:10.1039/c3nj01180a

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → methyl [2-(2-oxo-4-(3,4,5-trimethoxyphenyl)chroman)-6-yl]ethyl carbonate (1552301-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 8 h / Reflux

2: trifluoroacetic acid / 24 h / 25 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid;

DOI:10.1039/c3nj01180a

upstream raw materials:

p-hydroxyphenethyl alcohol

sinapinic acid

2-(4'-hydroxyphenyl)ethyl methyl carbonate

methyl 3,4,5-trimethoxycinnamate

Downstream raw materials:

3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(3,4,5-trimethoxyphenyl)propanoic acid