4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Base Information

Chemical Name:4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide
CAS No.:1264193-81-8
Molecular Formula:C₃₅H₅₀N₂O₅Si
Molecular Weight:606.878
Hs Code.:

4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Synonyms:4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Suppliers and Price of 4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

There total 7 articles about 4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264193-95-4
C₂₇H₄₄F₃NO₇SSi

: 7341-97-1
N-phenyl propynamide

: 1264193-81-8
4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Guidance literature:: N-phenyl propynamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

C₂₇H₄₄F₃NO₇SSi; In tetrahydrofuran; at -78 - -20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol102860r

Reference yield:

: C₃₄H₅₁NO₈Si

: 1264193-81-8
4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; N,N-dimethyl-formamide / 0.17 h / Microwave irradiation; Heating; Sealed tube

2.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

3.1: phenyllithium / tetrahydrofuran; dibutyl ether / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 1 h / -5 °C / Inert atmosphere

5.1: lithium diisopropyl amide / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

5.2: 18 h / -78 - -20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; phenyllithium; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dibutyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/ol102860r

Reference yield:

: 1264193-80-7
C₂₆H₄₅NO₅Si

: 1264193-81-8
4-{(2R,6R)-4-methylene-6-[(2R,4S,6R)-6-(2-methyloxazol-4-yl)-4-(triisopropylsilanyloxy)tetrahydropyran-2-ylmethyl]tetrahydropyran-2-yl}but-2-ynoic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 1 h / -5 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2.2: 18 h / -78 - -20 °C / Inert atmosphere

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol102860r