4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Base Information

Chemical Name:4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one
CAS No.:1293368-08-7
Molecular Formula:C₂₀H₂₀F₂N₂O₄
Molecular Weight:390.387
Hs Code.:

Synonyms:4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Suppliers and Price of 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

There total 6 articles about 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1293368-09-8
4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

: 1293368-08-7
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Guidance literature:: 4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one; With boron tribromide; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

With ammonium chloride; In dichloromethane;

Reference yield:

: 1293368-02-1
4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazin-2-one

: 1293368-08-7
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 1 h / 20 °C

2.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 1293368-08-7
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]-1-methylpiperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

4.2: 1 h / 20 °C

5.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With water; boron tribromide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;