7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

Base Information

Chemical Name:7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one
CAS No.:1312077-80-7
Molecular Formula:C₂₆H₂₀F₃NO₃S
Molecular Weight:483.511
Hs Code.:

Synonyms:7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

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Chemical Property of 7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

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Technology Process of 7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

There total 7 articles about 7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1312077-70-5
8-bromo-3,4-dihydro-1H-thiopyrano[4,3-b]quinolin-10(5H)-one

: 1312077-90-9
2-methyl-4-(4-(trifluoromethoxy)penoxy)phenylboronic acid

: 1312077-80-7
7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm200015a

Reference yield:

: 111-17-1
4-thiaheptane-1,7-dioic acid

: 1312077-80-7
7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: ethanol; sodium hydride / diethyl ether / 8 h / Reflux

3.1: acetic acid / benzene / 100 °C

3.2: Reflux

4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; sulfuric acid; sodium hydride; sodium carbonate; acetic acid; In diethyl ether; water; N,N-dimethyl-formamide; benzene; 3.1: Conrad-Limpach synthesis / 3.2: Conrad-Limpach synthesis / 4.1: Suzuki coupling;
DOI:10.1021/jm200015a

Reference yield:

: C₁₄H₁₀BrF₃O₂

: 1312077-80-7
7-(2-methyl-4-(4-(trifluoromethoxy)phenyl)phenyl)-1,3,4,10-tetrahydro-2-thia-10-azaanthracen-9-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 3.08 h / -78 °C

1.2: -78 - 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; sodium carbonate; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; 2.1: Suzuki coupling;
DOI:10.1021/jm200015a