Technology Process of (R)-2-((S)-(4-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid
There total 5 articles about (R)-2-((S)-(4-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium chloride / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
2: triethylamine; magnesium chloride / ethyl acetate / 72 h / 25 °C / Inert atmosphere
3: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere
4: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 0 - 25 °C / Inert atmosphere
5: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere
With
2,6-dimethylpyridine; t-butyldimethylsiyl triflate; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium chloride; magnesium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
2: |Aldol Condensation;
DOI:10.1021/jm4017224
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere
2: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 0 - 25 °C / Inert atmosphere
3: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere
With
2,6-dimethylpyridine; t-butyldimethylsiyl triflate; dihydrogen peroxide; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm4017224
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; magnesium chloride / ethyl acetate / 72 h / 25 °C / Inert atmosphere
2: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere
3: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 0 - 25 °C / Inert atmosphere
4: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere
With
2,6-dimethylpyridine; t-butyldimethylsiyl triflate; dihydrogen peroxide; triethylamine; trifluoroacetic acid; magnesium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
1: |Aldol Condensation;
DOI:10.1021/jm4017224
