[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Base Information

Chemical Name:[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid
CAS No.:1299467-00-7
Molecular Formula:C₂₃H₁₈F₂N₂O₅
Molecular Weight:440.403
Hs Code.:

Synonyms:[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Suppliers and Price of [7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

There total 5 articles about [7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299467-01-8
C₃₁H₃₄F₂N₂O₈

: 1299467-00-7
[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 1299466-87-7
2-bromo-3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoic acid methyl ester

: 1299467-00-7
[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 750585-90-1
methyl 2-bromo-3-(bromomethyl)benzoate

: 1299467-00-7
[7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-3-oxo-1,3-dihydroindazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.049