1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride

Base Information

• Chemical Name: 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride
• CAS No.: 1188907-38-1
• Molecular Formula: C₂₄H₂₅N₅O₄S*ClH
• Molecular Weight: 516.021
• Mol file: 1188907-38-1.mol

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride

Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride

There total 8 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea (1188907-37-0) + 6,7-dimethoxy-4-chloroquinazoline (13790-39-1) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride (1188907-38-1)

Guidance literature:

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea; With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Sonication;

6,7-dimethoxy-4-chloroquinazoline; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2011.07.019

Reference yield:

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea (1188907-37-0) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride (1188907-38-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Sonication;

Reference yield:

1,1'-(3,3'-disulfanediylbis(3,1-phenylene))bis(3-(5-tert-butylisoxazol-3-yl)urea) (1188907-34-7) → 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea hydrochloride (1188907-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; zinc / 50 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / Sonication

3.2: 4 h / 20 °C

With hydrogenchloride; sodium hydride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1016/j.bmcl.2011.07.019

upstream raw materials:

1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-ylthio)phenyl)urea

1,1'-(3,3'-disulfanediylbis(3,1-phenylene))bis(3-(5-tert-butylisoxazol-3-yl)urea)

1-(5-tert-butylisoxazol-3-yl)-3-(3-mercaptophenyl)urea

6,7-dimethoxy-4-chloroquinazoline