1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

Base Information

Chemical Name:1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole
CAS No.:884871-60-7
Molecular Formula:C₂₂H₂₇BrN₂O₃
Molecular Weight:447.372
Hs Code.:

Synonyms:1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

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Chemical Property of 1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

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Technology Process of 1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

There total 1 articles about 1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 884871-59-4
2-[1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-1H-imidazol-4-yl]-2-methylpropionaldehyde

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 884871-60-7
1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

Guidance literature:: With potassium carbonate; In methanol; at 0 - 20 ℃;
DOI:10.1021/jo060084f

Reference yield: 91.0%

: 884871-48-1
C₁₅H₁₃Br₃N₂O₄

: 884871-60-7
1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

: 884871-61-8
C₃₇H₄₀Br₄N₄O₇

Guidance literature:: 1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 0.583333h;

C₁₅H₁₃Br₃N₂O₄; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/jo060084f

Reference yield:

: 884871-60-7
1-benzyloxymethyl-2-bromo-5-(2,2-dimethyl[1,3]dioxolan-4-ylmethyl)-4-(1,1-dimethylprop-2-ynyl)-1H-imidazole

: 884871-73-2
C₃₄H₃₆Br₄N₄O₇

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / 0.58 h / -78 - 20 °C

1.2: 91 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 99 percent / TFA / tetrahydrofuran; H₂O / 20 °C

With trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1021/jo060084f