(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Base Information

Chemical Name:(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate
CAS No.:1269408-83-4
Molecular Formula:C₂HF₃O₂*C₂₁H₂₁FN₄O
Molecular Weight:478.446
Hs Code.:

Synonyms:(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Suppliers and Price of (2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

There total 6 articles about (2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1269407-89-7
1,1-dimethylethyl (2S)-2-({[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]amino}carbonyl)-1-azetidinecarboxylate

: 76-05-1
trifluoroacetic acid

: 1269408-83-4
(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1269408-83-4
(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 7.33 h / 0 - 20 °C

5: dichloromethane / 3 h / 20 °C

With hydrogenchloride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1269408-83-4
(2S)-N-[(3S)-1-(3-cyano-4'-fluoro-4-biphenylyl)-3-pyrrolidinyl]-2-azetidinecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 100 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 7.33 h / 0 - 20 °C

5: dichloromethane / 3 h / 20 °C

With hydrogenchloride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;