Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

Base Information

Chemical Name:Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate
CAS No.:945892-11-5
Molecular Formula:C₂₉H₂₇ClF₇N₃O₆
Molecular Weight:681.992
Hs Code.:

Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

Synonyms:Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

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Chemical Property of Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

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Technology Process of Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

There total 1 articles about Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 874482-98-1
2-chloro-4-trifluoromethoxy-benzylamine hydrochloride

: 945892-95-5
7-(4-Ethoxycarbonylpiperidin-1-yl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxylic Acid

: 945892-11-5
Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield: 65.0%

: 945892-11-5
Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate

: 945892-55-7
1-[3-({[2-Chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylic Acid

Guidance literature:: Ethyl 1-[3-({[2-chloro-4-(trifluoromethoxy)benzyl]amino}carbonyl)-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylate; With lithium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 48h;

With hydrogenchloride; water; In 1,4-dioxane;