Technology Process of N-[6-(2-fluoro-4-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
There total 8 articles about N-[6-(2-fluoro-4-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
dimethyl sulfoxide;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1016/j.bmc.2013.10.028
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos; lithium hexamethyldisilazane / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: pyridine / 4 h / 0 - 20 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C
4.1: trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 °C
4.2: pH 12 - 13
5.1: N,N-dimethyl acetamide / 3 h / 0 °C
6.1: methoxybenzene; trifluoroacetic acid / 3 h / 20 °C
7.1: caesium carbonate / dimethyl sulfoxide / 5 h / 20 °C / Inert atmosphere
With
pyridine; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; lithium hexamethyldisilazane; CyJohnPhos;
In
tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.10.028
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos; lithium hexamethyldisilazane / tetrahydrofuran / 4 h / 80 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: pyridine / 4 h / 0 - 20 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C
5.1: trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 °C
5.2: pH 12 - 13
6.1: N,N-dimethyl acetamide / 3 h / 0 °C
7.1: methoxybenzene; trifluoroacetic acid / 3 h / 20 °C
8.1: caesium carbonate / dimethyl sulfoxide / 5 h / 20 °C / Inert atmosphere
With
pyridine; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; caesium carbonate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; lithium hexamethyldisilazane; CyJohnPhos;
In
tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.10.028
