(S)-3-Phenyl-3-o-tolyloxy-propylamine

Base Information

• Chemical Name: (S)-3-Phenyl-3-o-tolyloxy-propylamine
• CAS No.: 191729-89-2
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.333
• Mol file: 191729-89-2.mol

Synonyms:(S)-3-Phenyl-3-o-tolyloxy-propylamine

Chemical Property of (S)-3-Phenyl-3-o-tolyloxy-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-Phenyl-3-o-tolyloxy-propylamine

There total 4 articles about (S)-3-Phenyl-3-o-tolyloxy-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-3-Phenyl-3-o-tolyloxy-propionitrile (191729-86-9) → (S)-3-Phenyl-3-o-tolyloxy-propylamine (191729-89-2)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 65 ℃; for 5h;

DOI:10.1016/S0040-4020(97)00325-6

Reference yield:

Trifluoro-methanesulfonic acid (R)-2-phenyl-2-o-tolyloxy-ethyl ester → (S)-3-Phenyl-3-o-tolyloxy-propylamine (191729-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 0.25 h

2: 96 percent / BH₃*SMe₂ / tetrahydrofuran / 5 h / 65 °C

With dimethylsulfide borane complex; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(97)00325-6

Reference yield:

(R)-2-Phenyl-2-o-tolyloxy-ethanol (191729-83-6) → (S)-3-Phenyl-3-o-tolyloxy-propylamine (191729-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h

2: dimethylformamide / 0.25 h

3: 96 percent / BH₃*SMe₂ / tetrahydrofuran / 5 h / 65 °C

With dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(97)00325-6

upstream raw materials:

(S)-3-Phenyl-3-o-tolyloxy-propionitrile

(R)-2-Phenyl-2-o-tolyloxy-ethanol

Downstream raw materials:

-(+)-tomoxetine hydrochloride

((S)-3-Phenyl-3-o-tolyloxy-propyl)-carbamic acid methyl ester

Refernces