N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

Base Information

Chemical Name:N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine
CAS No.:1397262-82-6
Molecular Formula:C₂₄H₂₉FN₂O₂
Molecular Weight:396.505
Hs Code.:

Synonyms:N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

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Chemical Property of N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

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Technology Process of N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

There total 3 articles about N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1397262-94-0
N-(benzofuran-2-ylmethyl)-N'-(hydroxybenzyl)homopiperazine

: 312-68-5
3-fluoropropyl tosylate

: 1397262-82-6
N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 20h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2012.07.026

Reference yield:

: 1397262-93-9
tert-butyl 4-(benzofuran-2-carbonyl)-homopiperazine-1-carboxylate

: 1397262-82-6
N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Reflux

With hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.026

Reference yield:

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 1397262-82-6
N-(benzofuran-2-ylmethyl)-N'-(4-(3-fluoropropoxy)benzyl)homopiperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Reflux

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.026