(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one
CAS No.:1527484-96-3
Molecular Formula:C₂₁H₂₀F₃NO₃
Molecular Weight:391.39
Hs Code.:

Synonyms:(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

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Chemical Property of (S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

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Technology Process of (S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

There total 3 articles about (S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 351-35-9
3-(trifluoromethyl)phenylacetic acid

: 3-lithio-4-benzyl-5,5-dimethyl-oxazolidin-2-one

: 1527484-96-3
(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

Guidance literature:: 3-(trifluoromethyl)phenylacetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 23 ℃; for 1.5h;

3-lithio-4-benzyl-5,5-dimethyl-oxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol403398u

Reference yield: 32.0%

: 2003-14-7
(3-trifluoromethyl-phenyl)-acetyl chloride

: 168297-85-6,352438-06-3
(S)-4-benzyl-5,5-dimethyloxazolidin-2-one

: 1527484-96-3
(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

Guidance literature:: (S)-4-benzyl-5,5-dimethyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

(3-trifluoromethyl-phenyl)-acetyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0039-1690793

Reference yield:

: 351-35-9
3-(trifluoromethyl)phenylacetic acid

: 1527484-96-3
(S)-4-benzyl-3-(2-(3-trifluoromethylphenyl)acetyl)-5,5-dimethyloxazolidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 23 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0039-1690793