1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline

Base Information

• Chemical Name: 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline
• CAS No.: 607736-24-3
• Molecular Formula: C₂₅H₂₀N₂O₂
• Molecular Weight: 380.446
• Mol file: 607736-24-3.mol

Synonyms:1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline

Chemical Property of 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline

There total 3 articles about 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(E)-2-[1-cyano-1-(4-methoxycarbonylphenyl)methylidene]-7-methyl-3-(2-tolyl)imino-2,3-dihydro-1H-indole → 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline (607736-24-3)

Guidance literature:

In dimethyl sulfoxide; at 180 ℃; for 48h;

DOI:10.1002/chem.200204566

Reference yield:

methyl 4-(cyanomethyl)benzoate (76469-88-0) → 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline (607736-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / NaH / tetrahydrofuran / 72 h / Heating

2: 40 percent / dimethylsulfoxide / 48 h / 180 °C

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/chem.200204566

Reference yield:

oxalic acid bis(2-tolylimidoyl) dichloride → 1,7-dimethyl-5-(4-methyloxycarbonylphenyl)-6H-indolino[3,2-b]quinoline (607736-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / NaH / tetrahydrofuran / 72 h / Heating

2: 40 percent / dimethylsulfoxide / 48 h / 180 °C

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/chem.200204566

upstream raw materials:

methyl 4-(cyanomethyl)benzoate

Downstream raw materials:

1,7-dimethyl-5-(4-carboxyphenyl)-6H-indolo[3,2-b]quinoline

1,7-dimethyl-5-(4-succinimidocarboxyphenyl)-6H-indolo[3,2-b]quinoline

C₂₈H₂₈N₄O