Technology Process of C28H34N2O2
There total 4 articles about C28H34N2O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl-methyl-amine; (5R,9R,13S,14S)-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxymorphinan-6-one;
With
toluene-4-sulfonic acid; benzoic acid;
In
benzene;
Reflux;
With
sodium cyanoborohydride;
In
ethanol;
at 0 - 20 ℃;
stereoselective reaction;
Molecular sieve;
DOI:10.1016/j.bmcl.2012.05.122
- Guidance literature:
-
With
sodium cyanoborohydride;
In
ethanol;
at 20 ℃;
stereoselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1016/j.tetlet.2020.152379
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: palladium on activated charcoal; hydrogen; acetic acid / 50 °C
3.1: toluene-4-sulfonic acid; benzoic acid / benzene / Reflux
3.2: 0 - 20 °C / Molecular sieve
With
palladium on activated charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; benzoic acid;
In
N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2012.05.122