6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

Base Information

Chemical Name:6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide
CAS No.:913182-59-9
Molecular Formula:C₂₃H₁₈FN₃O₂
Molecular Weight:387.413
Hs Code.:

6-(4-fluoro-phenyl)-<i>N</i>-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

Synonyms:6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

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Chemical Property of 6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

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Technology Process of 6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

There total 6 articles about 6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 913182-58-8
8-({[6-(4-fluoro-phenyl)-pyridine-3-carbonyl]-amino}-methyl)-quinoline-3-carboxylic acid ethyl ester

: 913182-59-9
6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.07.006

Reference yield:

: 913182-51-1
8-cyano-quinoline-3-carboxylic acid ethyl ester

: 913182-59-9
6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / H₂; N₂H₄ / RaNi

2: 80 percent / HBTU; iPr₂EtN / dimethylformamide

3: 70 percent / LiB(C₂H₅)3H / tetrahydrofuran

With hydrogen; lithium triethylborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrazine; RaNi; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.006

Reference yield:

: 77173-67-2
4-chloro-8-cyano-quinoline-3-carboxylic acid ethyl ester

: 913182-59-9
6-(4-fluoro-phenyl)-N-(3-hydroxymethyl-quinolin-8-ylmethyl)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / H₂; Et₃N / Pd / ethanol

2: 60 percent / H₂; N₂H₄ / RaNi

3: 80 percent / HBTU; iPr₂EtN / dimethylformamide

4: 70 percent / LiB(C₂H₅)3H / tetrahydrofuran

With hydrogen; lithium triethylborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; palladium; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.006