2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide
CAS No.:1245940-99-1
Molecular Formula:C₂₇H₂₂ClF₄N₅O₃
Molecular Weight:575.95
Hs Code.:

Synonyms:2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

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Chemical Property of 2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

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Technology Process of 2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

There total 3 articles about 2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 959139-49-2
[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

: 1183104-54-2
2-amino-2-[3-(trifluoromethyl)phenyl]propanamide

: 1245940-99-1
2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: [3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-amino-2-[3-(trifluoromethyl)phenyl]propanamide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 1245940-99-1
2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; ammonium chloride / ethanol; water / 20 h / 70 °C / Autoclave

2.1: hydrogenchloride; water / 20 °C / Cooling with ice

3.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 h / 20 °C

With hydrogenchloride; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; ammonia; water; ammonium chloride; benzotriazol-1-ol; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 953741-94-1
2-amino-2-[3-(trifluoromethyl)phenyl]propionitrile

: 1245940-99-1
2-({[3-(4-Chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 20 °C / Cooling with ice

2.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 20 °C

With hydrogenchloride; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; benzotriazol-1-ol; In N,N-dimethyl-formamide;