Technology Process of C17H20BrNO4
There total 1 articles about C17H20BrNO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl 2-(3-bromobenzyl)-malonate;
With
sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide; mineral oil;
at 20 ℃;
for 1h;
Inert atmosphere;
bromopropionitrile;
In
tetrahydrofuran; dimethyl sulfoxide; mineral oil;
for 60h;
Inert atmosphere;
DOI:10.1021/ol501058a
- Guidance literature:
-
With
lithium chloride;
In
dimethyl sulfoxide;
at 140 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/ol501058a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium chloride / dimethyl sulfoxide / 4 h / 140 °C / Inert atmosphere
2: lithium chloride; potassium borohydride / tetrahydrofuran / 24 h / Inert atmosphere; Reflux
3: triethylamine; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere
4: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere
5: sodium hydroxide; water / ethanol / 10 h / 85 °C / Inert atmosphere
6: oxalyl dichloride / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
dmap; sodium azide; potassium borohydride; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; triethylamine; lithium chloride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol501058a
