4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile
CAS No.:1028729-73-8
Molecular Formula:C₄₁H₅₅N₃O₂Si
Molecular Weight:649.992
Hs Code.:

Synonyms:4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

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Chemical Property of 4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

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Technology Process of 4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

There total 1 articles about 4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 5122-82-7
1-adamantyl bromomethyl ketone

: 69739-34-0
t-butyldimethylsiyl triflate

: 135689-65-5
4'-<(6-butyl-1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl><1,1'-biphenyl>-2-carbonitrile

: 1028729-73-8
4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

Guidance literature:: 1-adamantyl bromomethyl ketone; 4'-<(6-butyl-1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl><1,1'-biphenyl>-2-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 1 - 30 ℃; for 16h;

With sodium tetrahydroborate; In methanol; at 1 - 30 ℃; for 3h;

t-butyldimethylsiyl triflate; With 2,6-dimethylpyridine; water; ammonium chloride; more than 3 stages;

Reference yield: 24.0%

: 1028729-73-8
4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

: 530-62-1
1,1'-carbonyldiimidazole

: 1028704-66-6
3-[2-(1-adamantyl)-2-hydroxyethyl]-6-butyl-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}pyrimidin-4(3H)-one

Guidance literature:: 4'-{[1-(2-(1-adamantyl)-2-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile; With hydroxylamine hydrochloride; sodium hydrogencarbonate; In dimethyl sulfoxide; at 1 - 30 ℃; for 16.5h;

1,1'-carbonyldiimidazole; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 1 - 30 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 1 - 30 ℃; for 3h;