8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

Base Information

Chemical Name:8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one
CAS No.:915133-64-1
Molecular Formula:C₃₂H₃₆F₂N₂O₄
Molecular Weight:550.646
Hs Code.:

Synonyms:8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

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Chemical Property of 8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

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Technology Process of 8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

There total 3 articles about 8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 915133-63-0
8-(benzyloxy)-5-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}ethyl)quinolin-2(1H)-one

: 915133-64-1
8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 45 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 915132-93-3
6-(2,2-difluoro-2-phenyl-ethoxy)hexan-1-amine

: 915133-64-1
8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 2 h / 140 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 915132-92-2
2-[6-(2,2-difluoro-2-phenylethoxy)hexyl]-1H-isoindole-1,3(2H)-dione

: 915133-64-1
8-(benzyloxy)-5-((1R)-2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl] amino}-1-hydroxyethyl)quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; water; hydrazine / 20 °C

2: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 2 h / 140 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With ethanol; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; sodium iodide; hydrazine; In tetrahydrofuran; dimethyl sulfoxide;