(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

Base Information

Chemical Name:(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol
CAS No.:1228099-84-0
Molecular Formula:C₂₂H₃₃NO₂
Molecular Weight:343.51
Hs Code.:

Synonyms:(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

Chemical Property:

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Technology Process of (R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

There total 4 articles about (R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: (R)-2-(3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl)ethanol

: 2550-36-9
Cyclohexylmethyl bromide

: 1228099-84-0
(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2017.04.042

Reference yield:

: methyl (±)-3-hydroxy-4-phenylbutanoate

: 1228099-84-0
(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Amano Lipase PS-C II / tert-butyl methyl ether / 145 h / 20 °C / Inert atmosphere

2.1: toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 240 h / 20 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / 3 h / 100 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

With lithium borohydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; tert-butyl methyl ether; toluene; acetonitrile;
DOI:10.1016/j.bmc.2017.04.042

Reference yield:

: 312599-02-3
(R)-methyl 3-hydroxy-4-phenylbutanoate

: 1228099-84-0
(R)-2-[1'-(cyclohexylmethyl)-3,4-dihydrospiro[[2]benzopyran-1,4'-piperidin]-3-yl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 240 h / 20 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / 3 h / 100 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

With lithium borohydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.bmc.2017.04.042