(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1450666-75-7
Molecular Formula:C₂₃H₂₂F₃N₅O
Molecular Weight:441.456
Hs Code.:

Synonyms:(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Chemical Property:

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Technology Process of (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

There total 7 articles about (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450666-74-6
C₁₆H₁₈BrN₅O

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1450666-75-7
(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 16h; Inert atmosphere; Reflux;

Reference yield:

: C₁₁H₈ClN₃O

: 1450666-75-7
(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

2: N-Bromosuccinimide / 1,4-dioxane / 0.5 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;

Reference yield:

: 1450666-72-4
C₁₁H₉N₃O₂

: 1450666-75-7
(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 2 h / Cooling; Reflux

2: triethylamine / dichloromethane / 6 h / 0 - 20 °C

3: N-Bromosuccinimide / 1,4-dioxane / 0.5 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; thionyl chloride; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; 4: |Suzuki Coupling;