[2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide]

Base Information

• Chemical Name: [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide]
• CAS No.: 273216-87-8
• Molecular Formula: C₂₈H₂₄Cl₂N₄O₂
• Molecular Weight: 519.43
• Mol file: 273216-87-8.mol

Synonyms:[2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide]

Chemical Property of [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide]

There total 4 articles about [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,6'-Dibromo-2,2'-bipyridine (49669-22-9) → [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide] (273216-87-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 25 percent / BuLi / tetrahydrofuran

2: SOCl₂

4: SOCl₂

With n-butyllithium; thionyl chloride; In tetrahydrofuran; 1: Metallation / 1: Carbonylation / 2: Chlorination / 3: Condensation / 4: Chlorination;

DOI:10.1016/S0040-4039(00)00144-1

Reference yield:

[2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-hydroxy-1-phenyl-ethyl)-amide] → [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide] (273216-87-8)

Guidance literature:

With thionyl chloride;

DOI:10.1016/S0040-4039(00)00144-1

Reference yield:

2,2'-bipyridine-6,6'-dicarboxylic acid (4479-74-7) → [2,2']Bipyridinyl-6,6'-dicarboxylic acid bis-[((S)-2-chloro-1-phenyl-ethyl)-amide] (273216-87-8)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

3: SOCl₂

With thionyl chloride; 1: Chlorination / 2: Condensation / 3: Chlorination;

DOI:10.1016/S0040-4039(00)00144-1

upstream raw materials:

6,6'-Dibromo-2,2'-bipyridine

2,2'-bipyridine-6,6'-dicarboxylic acid

2,2′-bipyridine-6,6′-dicarbonyl dichloride

Downstream raw materials:

6,6'-Bis-((S)-4-phenyl-4,5-dihydro-oxazol-2-yl)-[2,2']bipyridinyl