Technology Process of 3-((1Z,3E)-5-Bromo-3-methyl-penta-1,3-dienyl)-2,4,4-trimethyl-cyclohex-2-enone
There total 8 articles about 3-((1Z,3E)-5-Bromo-3-methyl-penta-1,3-dienyl)-2,4,4-trimethyl-cyclohex-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / p-toluenesulfonic acid / 1.) 5 deg C, 2.) RT, 10 min
2: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h
3: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr
4: PBr3 / diethyl ether / 0.08 h / Ambient temperature
With
n-butyllithium; hydrogen; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid;
Lindlar's catalyst;
In
diethyl ether; toluene;
DOI:10.1021/jo00132a028
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LDA / 1.) THF, hexane, -60 deg C, 90 min, 2.) a) 3 min, b) RT, 2 h
2: 85 percent / NaH / methanol / 3 h / Heating
3: 91 percent / p-toluenesulfonic acid / benzene / 3 h / Heating
4: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h
5: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr
6: PBr3 / diethyl ether / 0.08 h / Ambient temperature
With
n-butyllithium; hydrogen; phosphorus tribromide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide;
Lindlar's catalyst;
In
methanol; diethyl ether; toluene; benzene;
DOI:10.1021/jo00132a028
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / NaH / methanol / 3 h / Heating
2: 91 percent / p-toluenesulfonic acid / benzene / 3 h / Heating
3: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h
4: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr
5: PBr3 / diethyl ether / 0.08 h / Ambient temperature
With
n-butyllithium; hydrogen; phosphorus tribromide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid;
Lindlar's catalyst;
In
methanol; diethyl ether; toluene; benzene;
DOI:10.1021/jo00132a028
