Technology Process of (R,E)-3-(3-methyl-5-oxocyclohex-3-enyl)but-2-enal
There total 6 articles about (R,E)-3-(3-methyl-5-oxocyclohex-3-enyl)but-2-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 1h;
Molecular sieve;
DOI:10.1021/ol2024554
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hydroxide / hexanes; water / 5 - 10 °C
1.2: 5 - 10 °C
2.1: 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate / tetrahydrofuran / 1.5 h / -40 - -30 °C / Inert atmosphere
3.1: oxygen; copper(l) chloride; palladium dichloride / water; N,N-dimethyl-formamide / 20 °C
4.1: C20H27N3O; acetic acid / toluene / 48 h / -15 - 0 °C / Inert atmosphere
5.1: diisobutylaluminium hydride / tetrahydrofuran; hexanes / 0.33 h / -78 °C / Inert atmosphere
6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C / Molecular sieve
With
1-methyl-pyrrolidin-2-one; tetrapropylammonium perruthennate; iron(III)-acetylacetonate; C20H27N3O; oxygen; diisobutylaluminium hydride; acetic acid; 4-methylmorpholine N-oxide; copper(l) chloride; palladium dichloride; lithium hydroxide;
In
tetrahydrofuran; hexanes; dichloromethane; water; N,N-dimethyl-formamide; toluene;
3.1: Wacker oxidation;
DOI:10.1021/ol2024554
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate / tetrahydrofuran / 1.5 h / -40 - -30 °C / Inert atmosphere
2: oxygen; copper(l) chloride; palladium dichloride / water; N,N-dimethyl-formamide / 20 °C
3: C20H27N3O; acetic acid / toluene / 48 h / -15 - 0 °C / Inert atmosphere
4: diisobutylaluminium hydride / tetrahydrofuran; hexanes / 0.33 h / -78 °C / Inert atmosphere
5: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C / Molecular sieve
With
1-methyl-pyrrolidin-2-one; tetrapropylammonium perruthennate; iron(III)-acetylacetonate; C20H27N3O; oxygen; diisobutylaluminium hydride; acetic acid; 4-methylmorpholine N-oxide; copper(l) chloride; palladium dichloride;
In
tetrahydrofuran; hexanes; dichloromethane; water; N,N-dimethyl-formamide; toluene;
2: Wacker oxidation;
DOI:10.1021/ol2024554
