5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE

Base Information

• Chemical Name: 5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE
• CAS No.: 325153-22-8
• Molecular Formula: C₁₂H₁₃N₃OS
• Molecular Weight: 247.321
• Mol file: 325153-22-8.mol

Synonyms:(5Z)-5-[(dimethylamino)methylene]-3-phenyl-2-thioxoimidazolidine-4-one

Chemical Property of 5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE 95.00% ^*data from reagent suppliers

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Technology Process of 5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE

There total 2 articles about 5-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-phenyl-2-thioxoimidazolidin-4-one (2010-15-3) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → (5Z)-5-[(dimethylamino)methylene]-3-phenyl-2-thioxoimidazolidine-4-one (325153-22-8) + 5-dimethylaminomethylidene-3-phenyl-2-ethylsulfanyl-3H-imidazol-4(5H)-one

Guidance literature:

at 70 ℃; for 0.5h; Irradiation;

DOI:10.1016/S0040-4039(02)02156-1

Reference yield:

phenyl isothiocyanate (103-72-0) → (5Z)-5-[(dimethylamino)methylene]-3-phenyl-2-thioxoimidazolidine-4-one (325153-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / diethyl ether / 15 h / Heating

2: 75 percent / 0.5 h / 70 °C / Irradiation

With TEA; In diethyl ether;

DOI:10.1016/S0040-4039(02)02156-1

Reference yield: 79.0%

2-methyl-1H-indole (95-20-5) + (5Z)-5-[(dimethylamino)methylene]-3-phenyl-2-thioxoimidazolidine-4-one (325153-22-8) → 5-[(Z)-(2-methyl-1H-indol-3-yl)methylidene]-3-phenyl-2-thioxoimidazolidin-4-one (681014-88-0)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 48h;

DOI:10.1016/S0040-4020(01)00838-9

upstream raw materials:

3-phenyl-2-thioxoimidazolidin-4-one

N,N-dimethylformamide diethyl diacetal

phenyl isothiocyanate

Downstream raw materials:

5-[(Z)-(2-methyl-1H-indol-3-yl)methylidene]-3-phenyl-2-thioxoimidazolidin-4-one

ethyl (2E,3E)-2-[(dimethylamino)methylene]-4,4,4-trifluoro-3-(5-oxo-1-phenyl-2-thioxoimidazolidin-4-ylidene)butanoate

dimethyl (2E,3E)-2-[(dimethylamino)methylene]-3-(5-oxo-1-phenyl-2-thioxoimidazolidin-4-ylidene)butanedioate

ethyl (2E,3Z).4-(dimethylamino)-2-(5-oxo-1-phenyl-2-thioxoimidazolidin-4-ylidene)but-3-enoate(5-oxo-1-phenyl-2-thioxoimidazolidin-4-ylidene)butanediooate

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