4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

Base Information

Chemical Name:4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid
CAS No.:1334492-86-2
Molecular Formula:C₃₅H₃₆N₂O₆S
Molecular Weight:612.747
Hs Code.:

Synonyms:4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

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Chemical Property of 4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

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Technology Process of 4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

There total 9 articles about 4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1334493-26-3
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)benzoate

: 1334492-86-2
4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.06.056

Reference yield: 97.0%

: 1334492-86-2
4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 3h;

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1334492-86-2
4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)-2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / methanol / 3 h / 45 °C / Inert atmosphere; Molecular sieve

2: sodium cyanoborohydride / methanol / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.17 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1016/j.bmcl.2011.06.056