C₃₈H₄₄N₆O₄

Base Information

• Chemical Name: C₃₈H₄₄N₆O₄
• CAS No.: 1273592-22-5
• Molecular Formula: C₃₈H₄₄N₆O₄
• Molecular Weight: 648.805
• Mol file: 1273592-22-5.mol

Synonyms:C₃₈H₄₄N₆O₄

Chemical Property of C₃₈H₄₄N₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₄₄N₆O₄

There total 6 articles about C₃₈H₄₄N₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C18H22IN3O2 (1242094-29-6) + C20H23N3O2 (1273592-36-1) → C38H44N6O4 (1273592-22-5)

Guidance literature:

With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 35 ℃; for 15h; Inert atmosphere;

Reference yield:

C18H24BrN3O3 (1256387-73-1) → C38H44N6O4 (1273592-22-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 3 h / 50 - 60 °C

2: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / acetonitrile / 85 °C / Inert atmosphere

3: potassium carbonate; methanol / 1.5 h / 20 °C

4: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / acetonitrile / 15 h / 35 °C / Inert atmosphere

With methanol; potassium carbonate; acetic acid; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile;

Reference yield:

(1R,3S,4S)-3-(6-bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester (1256387-74-2) → C38H44N6O4 (1273592-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / acetonitrile / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 1.5 h / 20 °C

3: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / acetonitrile / 15 h / 35 °C / Inert atmosphere

With methanol; potassium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

C₁₈H₂₂INO₅

C₁₈H₂₄BrN₃O₃

(1R,3S,4S)-3-(6-bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester