2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

Base Information

Chemical Name:2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal
CAS No.:1610700-33-8
Molecular Formula:C₂₃H₂₆ClFN₂O₂
Molecular Weight:416.923
Hs Code.:

Synonyms:2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

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Chemical Property of 2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

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Technology Process of 2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

There total 4 articles about 2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1366349-30-5
2'-(2-chloroethyl)-5'-fluoro-2',3'-dihydrospiro[[1,3]dioxolane-2,1'-indene]

: 13078-12-1,38869-46-4
1-(4-chlorophenyl)piperazine dihydrochloride

: 1610700-33-8
2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

Guidance literature:: With potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; for 12h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.026

Reference yield:

: 1366349-27-0
4-chloro-1-(4-fluorophenyl)-2-methylenebutan-1-one

: 1610700-33-8
2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 1 h / 60 °C

2: toluene-4-sulfonic acid / toluene / 48 h / Reflux; Inert atmosphere

3: potassium iodide; potassium carbonate / 1,2-dimethoxyethane / 12 h / Reflux; Inert atmosphere

With sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In 1,2-dimethoxyethane; toluene;
DOI:10.1016/j.bmc.2014.04.026

Reference yield:

: 1366349-29-2
2-(2-chloroethyl)-5-fluoro-2,3-dihydro-1H-inden-1-one

: 1610700-33-8
2-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethyl}-5-fluoro-indan-1-one ethylene acetal

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 48 h / Reflux; Inert atmosphere

2: potassium iodide; potassium carbonate / 1,2-dimethoxyethane / 12 h / Reflux; Inert atmosphere

With potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In 1,2-dimethoxyethane; toluene;
DOI:10.1016/j.bmc.2014.04.026