Menadione sodium bisulfite

Base Information

• Chemical Name: Menadione sodium bisulfite
• CAS No.: 130-37-0
• Molecular Formula: C11H9NaO5S
• Molecular Weight: 276.245
• Hs Code.: 2914700090
• Mol file: 130-37-0.mol

Synonyms:1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonic acid sodium salt;2,3-Dihydro-2-methyl-1,4-naphthoquinone-2-sulfonate sodium;Golagen K;Hykinone;Ido-K;Kavitamin;Kawitan;Klotogen F;Klotogen F 227;MSBC;Vikasol;Vitamin K injection;2-Naphthalenesulfonicacid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt (1:1);Bisulfite sodique de menadione [INN-French];CCRIS 7112;EINECS 204-987-0;UNII-6XF3C2HK77;Vikasolum;

Chemical Property of Menadione sodium bisulfite

Chemical Property:

• Appearance/Colour: Crystalline powder
• Melting Point: 121-124 °C
• PSA: 99.72000
• LogP: 1.84040
• Storage Temp.: −20°C
• Solubility.: H2O: ≥50mg/mL, clear, colorless to faintly yellow

Purity/Quality:

99%, ^*data from raw suppliers

Menadione sodium bisulfite ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N
• Statements: 36-50/53-36/38
• Safety Statements: 26-61-60-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Menadione sodium bisulfite has been used:as a priming agent in tomato for improving salt toleranceto induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissuesto induce endogenous superoxide production in mouse C17.2 neural stem cells
• Therapeutic Function: Prothrombogenic vitamin

Technology Process of Menadione sodium bisulfite

There total 6 articles about Menadione sodium bisulfite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

menadione (58-27-5,34524-96-4) → Hykinone (130-37-0)

Guidance literature:

With sodium hydrogensulfite; In ethanol; water; at 40 - 45 ℃; for 4h; Solvent; Temperature;

Reference yield: 17.1%

2-Methylnaphthalene (91-57-6,34468-07-0) → Hykinone (130-37-0)

Guidance literature:

With sodium hydrogen sulfite; In water; toluene; at 25 ℃; for 2h; Product distribution / selectivity;

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → Hykinone (130-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / 17 h / 40 - 82 °C

2: sodium hydroxide; dihydrogen peroxide; hydrogen bromide / dichloromethane; water / 25 - 30 °C

3: air / isopropyl alcohol / 5 h / 90 °C

4: sodium hydrogensulfite / water; ethanol / 4 h / 40 - 45 °C

With aluminum (III) chloride; hydrogen bromide; dihydrogen peroxide; sodium hydrogensulfite; sodium hydroxide; In ethanol; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

menadione

2-Methylnaphthalene

benzene

2-methyl-1-tetralone

Downstream raw materials:

menadione

Refernces

• 1、 -. "Preparation method of menadione sodium hydrogen sulfite". Paragraph 0059; 0082-0087. . Retrieved 2021/07/31.
• 2、 -. "A method for continuous preparation of menadione sodium bisulfite (by machine translation)". Paragraph 0041; 0042. . Retrieved 2017/03/17.