1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide

Base Information

Chemical Name:1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide
CAS No.:83472-51-9
Molecular Formula:C₁₇H₂₉ClN₆O₅
Molecular Weight:432.907
Hs Code.:
DSSTox Substance ID:DTXSID401003453
Wikidata:Q76156857

Synonyms:BRN 5663763;1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide;Glycinamide, 1-((methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)-;N-Methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide [French];83472-51-9;N-Methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide;C17H29ClN6O5;DTXSID401003453;C17-H29-Cl-N6-O5;LS-72209;N-[1-({2-[(2-Chloroethyl)amino]-1-hydroxyethylidene}amino)-4-methyl-1-oxopentan-2-yl]-1-[methyl(nitroso)carbamoyl]pyrrolidine-2-carboximidic acid

Suppliers and Price of 1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide

Chemical Property:

Density:1.39g/cm³
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:432.1887957
Heavy Atom Count:29
Complexity:617

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(=O)CNCCCl)NC(=O)C1CCCN1C(=O)N(C)N=O
Isomeric SMILES:CC(C)C[C@@H](C(=O)NC(=O)CNCCCl)NC(=O)[C@@H]1CCCN1C(=O)N(C)N=O

Technology Process of 1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide

There total 4 articles about 1-((Methylnitrosoamino)carbonyl)-L-prolyl-L-leucyl-N-(2-chloroethyl)glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 80354-50-3
N-methyl N-nitrosocarbamate de trichloro-2,4,5 phenyle

: chlorhydrate de L-prolyl L-leucylglycine chloro-2 ethylamide

: 83472-51-9
N-methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

Reference yield:

: 3469-47-4
N-carbobenzoxy L-leucylglycine chloro-2 ethylamide

: 83472-51-9
N-methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, cc. HCl / Pd/C / ethanol / 5 h

2: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

3: 98 percent / H₂, cc. HCl / Pd/C / ethanol / 5 h

4: 70 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: (S)-2-Amino-4-methyl-pentanoic acid [(2-chloro-ethylcarbamoyl)-methyl]-amide; hydrochloride

: 83472-51-9
N-methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycine chloro-2 ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

2: 98 percent / H₂, cc. HCl / Pd/C / ethanol / 5 h

3: 70 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;