[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Base Information

Chemical Name:[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid
CAS No.:1325712-38-6
Molecular Formula:C₂₁H₁₆F₄N₂O₂S
Molecular Weight:436.43
Hs Code.:

Synonyms:[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

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Chemical Property of [6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

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Technology Process of [6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

There total 7 articles about [6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1355045-75-8
[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid t-butyl ester

: 1325712-38-6
[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: [6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid t-butyl ester; With trimethylsilyl iodide; In 1,2-dichloro-ethane; Reflux;

With hydrogenchloride; water; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2011.10.073

Reference yield:

: 110977-72-5
C₉H₁₂O₅

: 1325712-38-6
[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water

2.1: 220 °C

3.1: Lawessons reagent / toluene / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: trimethylsilyl iodide / 1,2-dichloro-ethane / Reflux

With Lawessons reagent; trimethylsilyl iodide; sodium hydride; sodium hydroxide; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.073

Reference yield:

: 1355045-63-4
6-fluoro-2-(4-trifluoromethylbenzyl)-2,3,4,9-tetrahydro-β-carboline-1-thione

: 1325712-38-6
[6-fluoro-1-thioxo-2-(4-trifluoromethylbenzyl)-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: trimethylsilyl iodide / 1,2-dichloro-ethane / Reflux

With trimethylsilyl iodide; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.073