2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol

Base Information

• Chemical Name: 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol
• CAS No.: 199801-73-5
• Molecular Formula: C₂₀H₃₆O₄Si
• Molecular Weight: 368.589
• Mol file: 199801-73-5.mol

Synonyms:2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol

Chemical Property of 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol

There total 5 articles about 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 2-[(2S,6S)-2-(tert-butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethyl ester (349487-61-2) → 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol (199801-73-5)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)00258-7

Reference yield:

2-[(S)-6-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethanol (162089-63-6) → 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol (199801-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / pyridine / 1 h / 20 °C

2: 40 percent / CrO₃; pyridine / CH₂Cl₂ / 5.5 h

3: 62 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0 °C

4: imidazole / dimethylformamide / 1 h / 20 °C

5: 147 mg / potassium carbonate / methanol / 0.25 h / 20 °C

With pyridine; 1H-imidazole; chromium(VI) oxide; sodium tetrahydroborate; cerium(III) chloride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00258-7

Reference yield:

Acetic acid 2-[(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethyl ester (349487-58-7) → 2-[(2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethanol (199801-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 40 percent / CrO₃; pyridine / CH₂Cl₂ / 5.5 h

2: 62 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0 °C

3: imidazole / dimethylformamide / 1 h / 20 °C

4: 147 mg / potassium carbonate / methanol / 0.25 h / 20 °C

With pyridine; 1H-imidazole; chromium(VI) oxide; sodium tetrahydroborate; cerium(III) chloride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00258-7

upstream raw materials:

Acetic acid 2-[(2S,6S)-2-(tert-butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethyl ester

2-[(S)-6-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethanol

Acetic acid 2-[(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethyl ester

Acetic acid 2-[(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-2-oxo-cyclohex-3-en-(E)-ylidene]-ethyl ester

Downstream raw materials:

2,2,2-Trichloro-acetimidic acid 2-[(2S,6S)-2-(tert-butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(E)-ylidene]-ethyl ester

N-[(1R,2S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-1-vinyl-cyclohex-3-enyl]-2,2,2-trichloro-acetamide