N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide
CAS No.:850554-42-6
Molecular Formula:C₂₇H₃₂Cl₂N₄O₂
Molecular Weight:515.483
Hs Code.:

Synonyms:N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

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Chemical Property of N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

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Technology Process of N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

There total 10 articles about N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1021867-29-7
1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxylic acid

: 2213-43-6
1-Aminopiperidine

: 850554-42-6
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 74h;
DOI:10.1248/cpb.55.1213

Reference yield:

: 850554-41-5
1-(2,4-dichloro-phenyl)-4-methyl-5-{4-[5-(tetrahydro-pyran-2-yloxy)-pentyl]-phenyl}-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

: 850554-42-6
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: With toluene-4-sulfonic acid; In methanol;
DOI:10.1016/j.tetlet.2005.01.165

Reference yield:

: 288104-75-6
4-(4-bromo-phenyl)-2-[(2,4-dichloro-phenyl)-hydrazono]-3-methyl-4-oxo-butyric acid ethyl ester

: 850554-42-6
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-{4-(5-hydroxypentyl)phenyl}-4-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / AcOH / 48 h / Heating

2.1: 9-BBN / 16 h / 23 °C

2.2: 75 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 60 h / 120 °C

3.1: Me₃Al / CH₂Cl₂ / 1 h

3.2: 78 percent / CH₂Cl₂ / 48 h / 23 °C

4.1: PTSA / methanol

With 9-borabicyclo[3.3.1]nonane dimer; trimethylaluminum; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; 2.2: Suzuki coupling;
DOI:10.1016/j.tetlet.2005.01.165