5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile

Base Information

• Chemical Name: 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile
• CAS No.: 1208348-78-0
• Molecular Formula: C₁₈H₈ClF₇N₄
• Molecular Weight: 448.73

Synonyms:5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile

Chemical Property of 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile

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Technology Process of 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile

There total 1 articles about 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(3-chloro-5-trifluoromethylphenyl)-4,4,4-trifluoro-3-oxo-butyronitrile (1207530-18-4) + 2-fluoro-5-hydrazinobenzonitrile (161886-21-1) → 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile (1208348-78-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 170 ℃; for 0.2h; Microwave irradiation;

Reference yield: 45.0%

1,2,4-Triazole (288-88-0) + 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile (1208348-78-0) → 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-[1,2,4]triazol-1-ylbenzonitrile (1208339-61-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 0.25h;

Reference yield: 12.0%

5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-fluorobenzonitrile (1208348-78-0) + 2,4-dihydro-1,2,4-triazol-3-one (930-33-6,5311-58-0) → 5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-(5-oxo-4,5-dihydro[1,2,4]triazol-1-yl)benzonitrile (1208339-62-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.25h;

upstream raw materials:

2-(3-chloro-5-trifluoromethylphenyl)-4,4,4-trifluoro-3-oxo-butyronitrile

2-fluoro-5-hydrazinobenzonitrile

Downstream raw materials:

5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-[1,2,4]triazol-1-ylbenzonitrile

5-[5-amino-4-(3-chloro-5-trifluoromethylphenyl)-3-trifluoromethylpyrazol-1-yl]-2-(5-oxo-4,5-dihydro[1,2,4]triazol-1-yl)benzonitrile

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