1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

Base Information

Chemical Name:1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone
CAS No.:919114-22-0
Molecular Formula:C₂₀H₁₉N₅O₂S₂
Molecular Weight:425.535
Hs Code.:

1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-<i>b</i>]pyridin-5-yl]-ethanone

Synonyms:1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

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Chemical Property of 1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

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Technology Process of 1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

There total 4 articles about 1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 919114-10-6
5-acetyl-3-amino-4-(4-dimethylamino-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid hydrazide

: 75-15-0,12122-00-8
carbon disulfide

: 919114-22-0
1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

Guidance literature:: In pyridine; for 5h; Heating;
DOI:10.1080/10426500500330828

Reference yield:

: 919114-09-3
[5-acetyl-3-cyano-4-(4-dimethylamino-phenyl)-6-methyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester

: 919114-22-0
1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 6 h / Heating

2: 75 percent / pyridine / 5 h / Heating

With hydrazine hydrate; In pyridine; ethanol;
DOI:10.1080/10426500500330828

Reference yield:

: 121104-39-0
5-Acetyl-4-(4-dimethylamino-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

: 919114-22-0
1-[3-amino-4-(4-dimethylamino-phenyl)-2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaOMe / methanol / 4 h / Heating

2: hydrazine hydrate / ethanol / 6 h / Heating

3: 75 percent / pyridine / 5 h / Heating

With sodium methylate; hydrazine hydrate; In pyridine; methanol; ethanol;
DOI:10.1080/10426500500330828