(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

Base Information

Chemical Name:(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone
CAS No.:216310-80-4
Molecular Formula:C₃₀H₃₁Cl₂F₂N₅O₅
Molecular Weight:650.509
Hs Code.:

(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

Synonyms:(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

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Chemical Property of (+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

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Technology Process of (+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

There total 2 articles about (+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191353-92-1
(+)-3-(4-nitrophenoxycarbonyl)-4-(3,4-difluorophenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester

: 216311-22-7
1-(3-aminopropyl)-4-(2,4-dichlorophenyl)-piperidine-4-carbonitrile

: 216310-80-4
(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: {3-[4-Cyano-4(2,4-dichlorophenyl)-piperidin-1-yl}-propyl)-carbamic acid tert-butyl ester

: 216310-80-4
(+)-1-{3-[4-Cyano-4-(2,4-dichloro)phenylpiperidin-1-yl]propyl}aminocarbonyl-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxy-carbonyl-4-methoxymethyl-2-pyrimidone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: hydrogenchloride / tetrahydrofuran; dichloromethane

With hydrogenchloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;