2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt

Base Information

• Chemical Name: 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt
• CAS No.: 74514-63-9
• Molecular Formula: C₂HF₃O₂*C₁₂H₁₆ClNO₃S
• Molecular Weight: 403.807
• Mol file: 74514-63-9.mol

Synonyms:2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt

Chemical Property of 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt

There total 6 articles about 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-tert-Butoxycarbonylamino-4-chloro-5-(toluene-4-sulfinyl)-pentanoic acid benzhydryl ester (74514-66-2) + trifluoroacetic acid (76-05-1) → 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt (74514-63-9)

Guidance literature:

In various solvent(s); at 0 ℃; for 0.166667h;

DOI:10.1021/ja00532a042

Reference yield:

p-methylbenzenesulfenyl chloride (933-00-6) → 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt (74514-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0.33 h / Ambient temperature

2: m-chloroperbenzoic acid / CH₂Cl₂ / 50 h / Ambient temperature

3: 94 percent / various solvent(s) / 0.17 h / 0 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ja00532a042

Reference yield:

rac-allylglycine (1069-48-3,7685-44-1) → 2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt (74514-63-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 85.4 percent / triethylamine / H₂O; dioxane / 3.8 h / Ambient temperature

2: 80 percent / acetonitrile / 1 h / Ambient temperature

3: CH₂Cl₂ / 0.33 h / Ambient temperature

4: m-chloroperbenzoic acid / CH₂Cl₂ / 50 h / Ambient temperature

5: 94 percent / various solvent(s) / 0.17 h / 0 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;

DOI:10.1021/ja00532a042

upstream raw materials:

2-tert-Butoxycarbonylamino-4-chloro-5-(toluene-4-sulfinyl)-pentanoic acid benzhydryl ester

trifluoroacetic acid

p-methylbenzenesulfenyl chloride

rac-allylglycine